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The design of a stability study intends to establish a procedure to extract reliable data to determine the shelf life, which is based on testing a limited number of batches of a drug product and will be applicable to all future batches of the drug product that will be manufactured under similar conditions Designing long-term stability studies usually involves the determination of the following factors: number of batches, strength, packaging con gurations, and storage conditions Essentially, the stability process design includes the application of matrixing and bracketing design Section 723 presents a description of the conventional procedure to determine the shelf life, which is established based on longterm stability studies that are conducted under normal storage conditions Calculation of a drug product shelf life for single and multiple batches will be discussed and illustrated by examples.

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A set of computer programs are included in the Appendix to carry out the stability calculations Section 724 discusses the accelerated stability testing procedure, which is often used to provide a tentative shelf life At the early stage of a drug product development, the primary goal of the stability studies is to determine the rates of chemical and physical reactions and their relationships with storage conditions such as temperature, moisture, light, and others A short-term stability study is conducted under stressed conditions to increase the rate of chemical and physical degradation of the drug product This section will discuss the chemical reaction kinetics and the statistical procedure to establish a preliminary shelf life This section will cover the regression techniques to estimate the parameters of the Arrhenius equation..

c# itextsharp read pdf image

Extract image from PDF using .Net c# - Stack Overflow
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extract images from pdf using itextsharp in c#

C# tutorial: extract images from a PDF file
In this C# tutorial you will learn to extract images from a PDF file by using iTextSharp library.

These arrays contain information on three books by Steinbeck. You can see that array_multisort() has sorted all the arrays by author in ascending order as before. However, it has also sorted the three Steinbeck books East of Eden, Of Mice and Men, and The Grapes of Wrath into ascending order. You can also use array_multisort() to sort multidimensional arrays. This works in much the same way as for multiple arrays, except that you only pass in one array. The function then sorts the array by the first element of each nested array, then by the second element of each nested array, and so on. The order of the elements in the nested array is untouched. The following code illustrates how array_multisort() sorts a two-dimensional array. Figure 6-6 shows the output from the script.

FIGURE 10.19. A lens with spherical aberration, illuminated by an aberrated wavefront that just matches the spherical aberration of the lens. The refracted wavefront is spherical.

Many Palm and PocketPC devices have built-in Bluetooth capabilities. They are in fact ideal applications for Bluetooth. We don t cover using Bluetooth and PDAs in this chapter, however. For information on this topic, see 13.

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