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The kidneys can produce urine that is hypo-osmotic, iso-osmotic, or hyperosmotic The production of hypo-osmotic urine is, we hope by now, an understandable process: The tubules (particularly the thick ascending limb of Henle s loop) reabsorb relatively more solute than water, and the dilute fluid that remains in the lumen is excreted The production of hyperosmotic urine is also straightforward in that reabsorption of water from the lumen into a hyperosmotic interstitium concentrates that luminal fluid, leaving a concentrated urine to be excreted The question is, how do the kidneys generate a hyperosmotic medullary interstitium Not only is the medullary interstitium hyperosmotic, but there is a gradient of osmolality, increasing from a nearly iso-osmotic value at the corticomedullary border, to a maximum of greater than 1000 mOsm/kg at the papilla This peak value is not rigidly fixed; it is a variable that changes depending on conditions It is highest during periods of water deprivation and dehydration, when urinary excretion is lowest, and is washed out to only about half of that during excess hydration and urinary excretion is high Some aspects of how the kidneys generate a medullary osmotic gradient are still uncertain However, the essential points are clear, and it is these essential points on which we now focus We should first differentiate between the development of the medullary osmotic gradient, as opposed to its maintenance once established In the steady state, there must be mass balance, ie, every substance that enters the medulla via tubule or blood vessel must leave the medulla via tubule or blood vessel However, during development of the gradient there are transient accumulations of solute, and during washout of the gradient there are losses In describing the medullary osmotic gradient, it is easiest conceptually to start from a condition in which there is no gradient, and then follow its development over time The main components of the system that develops the medullary osmotic gradient are (1) active NaCl transport by the thick ascending limb; (2) the unusual arrangement of blood vessels and nephron segments in the medulla, with descending components in close apposition to ascending components; and (3) the recycling of urea between the medullary collecting ducts and the deep portions of the loops of Henle (Figure 5 3) To develop the osmotic gradient in the medullary interstitium, there must be deposition of solute in excess of water It is reabsorption of sodium and chloride by the thick ascending limb that accomplishes this task At the junction between the.

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Creating a Coordinate object from its string representation Creating an interface for editing the property

The easiest way to work around these issues is to create two properties for Coordinate: a Latitude and a Longitude property. Doing so would solve both problems, but that s not the best approach. Instead, you can leverage some of the .NET Framework s features.

Along with IP addresses, DHCP servers provide IP address attributes to their clients These attributes are either global (that is, they are provided to all clients) or local (that is, they are provided to only those clients within a given address scope) These attributes may change from time to time, so you will need to modify existing attributes or add new attributes In the DHCP console, these attributes are called scope options Global scope options should include at least the following: 003 Router: The address of a router 006 DNS Servers: The address of at least two DNS servers

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Create a type converter The .NET Framework has classes and methods that allow you to convert types from one to another. The ExpandableObjectConverter class, defined in System.ComponentModel, is a base class that converts an expandable object to another representation. In

015 DNS Domain Name: The domain name for the scope 044 WINS/NBNS Servers: The address of at least two WINS servers 046 WINS/NBT Node Type: This should be set to H-node H-node resolution is best even in wide area networks because it greatly reduces the amount of broadcasting on each network

this scenario, you ll use this class to create an automatic conversion from the Coordinate class to a string representation, and vice versa. To create the converter, start by adding a new class to the project; name it CoordinateConverter. It s common to name converters with the object name and append Converter to the class name. Add using statements so that you have access to the converter and globalization namespaces:

.

using System.ComponentModel; using System.Globalization;

3 3 3 3

Then make the class inherit from ExpandableObjectConverter and implement it, as shown in listing 5.13.